The IFC autopurification
platform was developed based on the proven reliability and productivity
of CTC's PAL series of LC/LC-MS sample loaders. The IFC PAL combines
sample injection and fraction collection with unmatched capacity
and versatility. The dual-probe design allows the complete separation
of injection and collection flow paths. High concentrated samples
can never cross-contaminate low concentrated fractions.
Additionally the commonly used 3-way fraction collector diverter
valve is replaced by a unique sidehole syringe valve which enables
an extremely low dead volume between valve and collection outlet.
This special diverter valve design further prevents fraction carryover.
The IFC PAL dual-probe design provides true high throughput processing
never achieved before by conventional autopurification solutions.
During fraction collection the next sample injection is already
prepared and executed. Overlapping the two processes results in
dramatically faster cycle times compared to single-probe systems.
High throughput purification demands real high sample and fraction
capacity. It makes little sense to use highly automated purification
systems with a limited sample capacity. Starting with crude samples,
the IFC PAL fraction bed accommodates up to 1092 pcs. test tubes
in semipreparative mode and 24 microplates or 1296 pcs.2ml vials
in analytical mode.
The IFC PAL is available in two different system configurations.
The analytical version consists of up to 5 sample stacks each holding
324 2ml vials or 6 deepwell plates / standard plates (96 or 384
wells). The semi-preparative version includes one sample trayholder
and 14 test tube trays in a wide variety of tube sizes. Both systems
contain carefully adapted hardware components to meet the specific
needs of the two different applications.
Both systems are delivered with the IFC PAL software package dedicated
for the fraction collection process. Each single step from injection
to fractionation can be controlled in a easy and straightforward
way.
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